Irf2bp2 cancer

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August undefined, 2024

WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... To access cancer specific RNA and … WebApr 25, 2024 · Additionally, IRF2BP2 may be involved in cancer development. Finally, it has been recently reported that IRF2BP2 may play a role in macrophage regulation and lymphocyte activation, highlighting ...

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WebInterferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 and the Hippo … WebApr 25, 2024 · The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2) and is an IRF-2 … importance of emergency management plan

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WebJul 29, 2024 · Translocations and mutations in the human irf2bp2gene have been observed in various cancers including primary central nervous system lymphoma (Pall & Hamilton, 2008), multiple myeloma (Ni et al.,2012), mesenchymal chondrosarcoma (Nyquist et al.,2012) and acute promyelocytic leukemia (Yin et al.,2015), emphasizing the importance … WebJul 30, 2024 · The levels of the co-transcriptional regulator IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein-2) decrease with T cell activation and, when ectopically expressed, it reduces T cell proliferation. To further characterize the function of IRF2BP2 in T cell responses in vivo, we generated a conditional transgenic knock-in mouse that … WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of … importance of emergency trolley

IRF2BP2 interferon regulatory factor 2 binding protein 2

IRF2BP2 (gene) - Wikipedia

WebNational Center for Biotechnology Information WebObjective: Primary central nervous system lymphoma (PCNSL) is a specific type of non-Hodgkin lymphoma with poor prognosis. The rare incidence of this disease and difficulty to obtain sufficient tissue material impede deep research into PCNSL. However, application of modern molecular techniques makes it possible to find biological characteristics … literacy worldWebSep 25, 2015 · IRF2BP2 is required for the expression of the anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2). Restoring KLF2 in IRF2BP2-deficient macrophages … literacy world comprehension

"WebSep 20, 2024 · The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally … " - Irf2bp2 cancer

Irf2bp2 cancer

The rare IRF2BP2-RARA fusion in acute promyelocytic leukemia

WebApr 1, 2024 · Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds to various RNA transcripts and promotes cancer progression, although little is known regarding its regulation. Here we show IGF2BP2 is a substrate of the deacetylase and tumor suppressor sirtuin 1 (SIRT1) and regulates the expression of the vacuolar ATPase subunit ATP6V1A. WebMar 21, 2024 · IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Diseases associated with IRF2BP2 include Immunodeficiency, Common …

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WebJul 6, 2024 · We identified the immune modulator IRF2BP2 as a selective AML dependency. We validated AML cell dependency on IRF2BP2 with genetic and protein degradation … WebJan 1, 2024 · For example, IRF2BP2 is confirmed to be upregulated in gastric cancer, and its deficiency impedes cell proliferation and epithelial-mesenchymal transition. 42 IRF2BP2 represses liver cancer progression via stabilizing VGLL4 and further enhancing VGLL4’s inhibitory effects on Hippo pathway. 43 In our study, we discovered that IRF2BP2 might …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and …

WebSep 25, 2015 · In a recent issue of Circulation Research, Chen et al report that IRF 2–binding protein 2 (IRF2BP2) is a novel regulator of macrophage inflammation and lipid homeostasis that acts by maintaining anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2) expression, therefore reducing susceptibility to atherosclerosis 6 ( Figure 2 ). WebCÁNCER DE PULMÓN El gen ALK (Anaplastic Lymphoma Kinase) y el gen EML4 (Echinoderm microtubule associated protein-like 4) se encuentran situados en el brazo corto del cromosoma 2, separados por 12 megabases de secuencia, y orientados en direcciones opuestas. Se ha descrito recientemente que alrededor del 5% de los carcinomas de …

WebMay 19, 2016 · The IRF2BP2–CDX-1 fusion gene has been reported in mesenchymal chondrosarcoma, 16 and there is one previous report of IRF2BP2–RARA in APL. 10 Yin et al. 10 reported a case of APL with IRF2BP2–RARA that involved exon 2 of IRF2BP2 and intron 2 of RARA, with breakpoints at positions 1687 bp in IRF2BP2 and 41620 bp in RARA. The …

WebJul 20, 2015 · IRF2BP2 is a cofactor modulating IRF2 and myocyte enhancer factor 2 (MEF2), transcription factors important for innate immunity and gene expression in macrophages. 8 – 12 Exposure of macrophages to bacterial lipopolysaccharide activates the M1 inflammatory phenotype, whereas exposure to interleukin (IL)-4 favors the M2 anti … importance of emerging economies for businessWebApr 25, 2024 · Abstract. The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2 literacy world stage 1WebMar 17, 2024 · The data show that IRF2BP2 is a novel target gene repressed by the YAP-TEAD transcriptional complex, and exhibits potent antitumor activity by inhibiting YAP activity. The researchers identify that IRF2BP2 interacts with VGLL4 and stabilizes the protein level of VGLL4, which leads to synergistic inhibition toward YAP. literacy work stations debbie dillerWebJun 15, 2024 · Recently, interferon regulatory protein 2 binding protein 2 ( IRF2BP2) emerged as a new RARA partner and was studied by next-generation RNA-sequencing analysis. IRF2BP2 has also been involved in other solid tumors [ 2, 3, 4 ]. Fig. 1 A Wright-Giemsa staining of abnormal promyelocytes at diagnosis. B Alpha naphthol acetate … importance of emerging technologyNational Center for Biotechnology Information importance of emissivityWebIRF2BP2-NTRK1 Fusion is present in 0.02% of AACR GENIE cases, with sarcoma, NOS, breast invasive ductal carcinoma, gastric adenocarcinoma, lung adenocarcinoma, and … importance of emotion in learningWebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid... importance of emotional regulation in adults