WebNov 23, 2015 · Gpnmb expression in the liver was stimulated four days after CCl4 injection. Histological examination and flow cytometry showed that Gpnmb-positive cells were … WebMar 24, 2024 · Pulmonary fibrosis (PF) is a form of progressive lung disease characterized by chronic inflammation and excessive extracellular matrix (ECM) deposition. The …
GPNMB: a potent inducer of immunosuppression in cancer
WebDec 15, 2024 · Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment … WebTGFβ downregulated GPNMB and decreased the release of its soluble form in normal fibroblasts. In dcSSc fibroblasts, GPNMB is upregulated by its own soluble form. Our data demonstrate an... tata index fund sensex direct plan
GPNMB contributes to a vicious circle for chronic obstructive …
WebApr 7, 2024 · Identifying key macrophage populations found in human fibrotic tissues could lead to new treatments for fibrosis. Here, we used human liver and lung single-cell RNA sequencing datasets to identify a subset of CD9 + TREM2 + macrophages that express SPP1, GPNMB, FABP5, and CD63. In both human and murine hepatic and pulmonary … WebFeb 15, 2024 · Pulmonary fibrosis (PF) is a form of progressive lung disease characterized by chronic inflammation and excessive extracellular matrix (ECM) deposition. The … WebSep 16, 2024 · In that model, deletion of GPNMB led to an increase in metalloproteinases 19 (MMP19) and fibrinolysis (Kumagai et al., 2015), suggesting that high expression of GPNMB might be important in regulation of fibrosis driven by HO-1 deficiency in Mϕ. Interestingly, this was accompanied by increased Marco expression, a scavenger … tata index sensex fund direct growth